Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-
cells and can occur either as sporadic or as hereditary diseases in the context of familial …

Growth hormone (GH)-secreting pituitary tumours represent the most genetically determined
pituitary tumour type. This is true both for germline and somatic mutations. Germline …

Context Pathogenic germline MAX variants are associated with pheochromocytoma and
paraganglioma (PPGL), pituitary neuroendocrine tumors and, possibly, other endocrine and …

Introduction Ectopic acromegaly is a rare condition caused most frequently by growth
hormone releasing hormone (GHRH) secretion from neuroendocrine tumors. The diagnosis …

Neuroendocrine tumours may be either benign or malignant tumours, and have the ability to
synthesise and secrete biologically active substances characteristic of the cell of origin that …

Context: Ectopic GHRH secretion is a rare cause of acromegaly, and case reports are mainly
isolated. Setting: From the registry of the sole laboratory performing plasma GHRH assays in …

Acromegaly secondary to extra-pituitary tumors secreting growth hormone releasing
hormone (GHRH) is rarely encountered. We review the literature on ectopic acromegaly and …

Dear Readers, Having served as Editor-in-Chief of Journal of Molecular Endocrinology for
seven years, I would like to take this opportunity to thank all those who have contributed to …

Background Ectopic hormone-secreting pheochromocytomas are rare; only case reports
exist in the literature. This condition has been linked with increased malignancy, familial …

A male patient with a germline mutation in MEN1 presented at the age of 18 with classical
features of gigantism. Previously, he had undergone resection of an insulin-secreting …