Genetics of human female infertility

SA Yatsenko, A Rajkovic - Biology of reproduction, 2019 - academic.oup.com
About 10% of women of reproductive age are unable to conceive or carry a pregnancy to
term. Female factors alone account for at least 35% of all infertility cases and comprise a …

The effects of chemical and physical factors on mammalian embryo culture and their importance for the practice of assisted human reproduction

PL Wale, DK Gardner - Human reproduction update, 2016 - academic.oup.com
BACKGROUND Although laboratory procedures, along with culture media formulations,
have improved over the past two decades, the issue remains that human IVF is performed in …

[HTML][HTML] Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer

DK Gardner, M Lane, J Stevens, T Schlenker… - Fertility and sterility, 2000 - Elsevier
Objective: To determine the relationship between blastocyst score and pregnancy outcome.
Design: Retrospective review of blastocyst transfer in an IVF clinic. Setting: Private assisted …

Culture and transfer of human blastocysts

DK Gardner, WB Schoolcraft - Current Opinion in Obstetrics and …, 1999 - journals.lww.com
The transfer of the human embryo at the blastocyst stage during an in-vitro fertilization
procedure is a way of increasing implantation rates. This, in turn, means that significantly …

Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and 'OMICS': is looking good still important?

DK Gardner, B Balaban - MHR: Basic science of reproductive …, 2016 - academic.oup.com
With the worldwide move towards single embryo transfer there has been a renewed focus
on the requirement for reliable means of assessing embryo viability. In an era of …

Metabolic remodelling during early mouse embryo development

J Zhao, K Yao, H Yu, L Zhang, Y Xu, L Chen, Z Sun… - Nature …, 2021 - nature.com
During early mammalian embryogenesis, changes in cell growth and proliferation depend
on strict genetic and metabolic instructions. However, our understanding of metabolic …

Large offspring syndrome in cattle and sheep.

LE Young, KD Sinclair, I Wilmut - Reviews of reproduction, 1998 - europepmc.org
Bovine and ovine embryos exposed to a variety of unusual environments prior to the
blastocyst stage have resulted in the development of unusually large offspring which can …

A critical appraisal of cryopreservation (slow cooling versus vitrification) of human oocytes and embryos

DH Edgar, DA Gook - Human reproduction update, 2012 - academic.oup.com
BACKGROUND Vitrification is now a commonly applied technique for cryopreservation in
assisted reproductive technology (ART) replacing, in many cases, conventional slow cooling …

A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization.

DK Gardner, WB Schoolcraft, L Wagley… - Human reproduction …, 1998 - academic.oup.com
The effectiveness of blastocyst culture and transfer in human in-vitro fertilization (IVF) was
evaluated in a prospective randomized trial in patients having a moderate to good response …

[PDF][PDF] Mutations in PADI6 cause female infertility characterized by early embryonic arrest

Y Xu, Y Shi, J Fu, M Yu, R Feng, Q Sang… - The American Journal of …, 2016 - cell.com
Early embryonic arrest is one of the major causes of female infertility. However, because of
difficulties in phenotypic evaluation, genetic determinants of human early embryonic arrest …