[HTML][HTML] Proteomics of Toxigenic Corynebacteria

A Burkovski - Proteomes, 2024 - mdpi.com
Within the genus Corynebacterium, six species are potential carriers of the tox gene, which
encodes the highly potent diphtheria exotoxin: Corynebacterium diphtheriae …

Neuroprotective potential of synthetic mono-carbonyl curcumin analogs assessed by molecular docking studies

H Hussain, S Ahmad, SWA Shah, M Ghias, A Ullah… - Molecules, 2021 - mdpi.com
Cognitive decline in dementia is associated with deficiency of the cholinergic system. In this
study, five mono-carbonyl curcumin analogs were synthesized, and on the basis of their …

Attenuation of scopolamine-induced amnesia via cholinergic modulation in mice by synthetic curcumin analogs

H Hussain, S Ahmad, SWA Shah, A Ullah, N Ali… - Molecules, 2022 - mdpi.com
Alzheimer's disease is an emerging health disorder associated with cognitive decline and
memory loss. In this study, six curcumin analogs (1a–1f) were synthesized and screened for …

Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs against them: An in silico approach

A Sahu, M Gaur, NC Mahanandia, E Subudhi… - Computers in Biology …, 2023 - Elsevier
Monkeypox virus (mpox virus) outbreak has rapidly spread to 82 non-endemic countries.
Although it primarily causes skin lesions, secondary complications and high mortality (1 …

Differential analysis of Orientia tsutsugamushi genomes for therapeutic target identification and possible intervention through natural product inhibitor screening

Z Basharat, U Akhtar, K Khan, G Alotaibi, K Jalal… - Computers in Biology …, 2022 - Elsevier
Orientia tsutsugamushi (Ott) is a causative agent of scrub typhus, and one of the emerging
pathogens that could affect a large human population. It is one of the misdiagnosed and …

Genome-Based Drug Target Identification in Human Pathogen Streptococcus gallolyticus

NA Qureshi, SM Bakhtiar, M Faheem, M Shah… - Frontiers in …, 2021 - frontiersin.org
Streptococcus gallolysticus (Sg) is an opportunistic Gram-positive, non-motile bacterium,
which causes infective endocarditis, an inflammation of the inner lining of the heart. As Sg …

Network-Based Metabolism-Centered Screening of Potential Drug Targets in Klebsiella pneumoniae at Genome Scale

MF Cesur, B Siraj, R Uddin, S Durmuş… - Frontiers in cellular and …, 2020 - frontiersin.org
Klebsiella pneumoniae is an opportunistic bacterial pathogen leading to life-threatening
nosocomial infections. Emergence of highly resistant strains poses a major challenge in the …

[HTML][HTML] Reverse vaccinology and subtractive genomics reveal new therapeutic targets against Mycoplasma pneumoniae: a causative agent of pneumonia

TCV Rodrigues, AK Jaiswal, A de Sarom… - Royal Society Open …, 2019 - ncbi.nlm.nih.gov
Pneumonia is an infectious disease caused by bacteria, viruses or fungi that results in
millions of deaths globally. Despite the existence of prophylactic methods against some of …

Genomic landscape of the emerging XDR Salmonella Typhi for mining druggable targets clpP, hisH, folP and gpmI and screening of novel TCM inhibitors, molecular …

M Afzal, SS Hassan, S Sohail, I Camps, Y Khan… - BMC microbiology, 2023 - Springer
Typhoid fever is transmitted by ingestion of polluted water, contaminated food, and stool of
typhoid-infected individuals, mostly in developing countries with poor hygienic …

Reverse vaccinology and subtractive genomics reveal new therapeutic targets against Mycoplasma pneumoniae: a causative agent of pneumonia

TC Vilela Rodrigues, AK Jaiswal… - Royal Society …, 2019 - royalsocietypublishing.org
Pneumonia is an infectious disease caused by bacteria, viruses or fungi that results in
millions of deaths globally. Despite the existence of prophylactic methods against some of …