Endometriosis is a common condition associated with infertility that causes chronic pain in
many, but not all, women. It is defined by the presence of endometrial-like tissue outside the …

In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research
into the mechanisms underlying response to ICB has predominantly focused on T cells; …

Interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) are alarmins that are
released upon airway epithelial injury from insults such as viruses and cigarette smoke, and …

Microbial dysbiosis in the skin has been implicated in the pathogenesis of atopic dermatitis
(AD); however, whether and how changes in the skin microbiome initiate skin inflammation …

Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Tremendous progress in the last few years has been made to explain how seemingly
harmless environmental proteins from different origins can induce potent Th2‐biased …

Atopic dermatitis (AD) is one of the most prevalent inflammatory disease among non-fatal
skin diseases, affecting up to one fifth of the population in developed countries. AD is …

An aneuploid-immune paradox encompasses somatic copy-number alterations (SCNAs),
unleashing a cytotoxic response in experimental precancer systems, while conversely being …

The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …