Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …
Emerging delivery approaches for targeted pulmonary fibrosis treatment
Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …
[HTML][HTML] Dysregulation of metabolic pathways in pulmonary fibrosis
R Rajesh, R Atallah, T Bärnthaler - Pharmacology & Therapeutics, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder of unknown origin and
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …
Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis
B Selvarajah, I Azuelos, D Anastasiou… - Science Signaling, 2021 - science.org
Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …
Connective tissue growth factor in idiopathic pulmonary fibrosis: breaking the bridge
WI Effendi, T Nagano - International Journal of Molecular Sciences, 2022 - mdpi.com
CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …
Metabolic reprogramming of pulmonary fibrosis
J Li, X Zhai, X Sun, S Cao, Q Yuan… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …
[HTML][HTML] Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by
myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene …
myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene …
Glycolysis Reprogramming in Idiopathic Pulmonary Fibrosis: Unveiling the Mystery of Lactate in the Lung
P Yan, J Liu, Z Li, J Wang, Z Zhu, L Wang… - International Journal of …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized
by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence …
by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence …
Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model
E Schruf, V Schroeder, HQ Le… - The FASEB …, 2020 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown cause that is characterized
by progressive fibrotic lung remodeling. An abnormal emergence of airway epithelial‐like …
by progressive fibrotic lung remodeling. An abnormal emergence of airway epithelial‐like …
An optical pH-sensor integrated microfluidic platform multilayered with bacterial cellulose and gelatin methacrylate to mimic drug-induced lung injury
Drug-induced lung injury leading to pulmonary fibrosis is an interstitial lung pathology
destructing the architecture of lung. Although animal models have been used to understand …
destructing the architecture of lung. Although animal models have been used to understand …