Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation

AA Gibb, MP Lazaropoulos, JW Elrod - Circulation research, 2020 - Am Heart Assoc
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Emerging delivery approaches for targeted pulmonary fibrosis treatment

R Diwan, HN Bhatt, E Beaven, M Nurunnabi - Advanced drug delivery …, 2024 - Elsevier
Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …

[HTML][HTML] Dysregulation of metabolic pathways in pulmonary fibrosis

R Rajesh, R Atallah, T Bärnthaler - Pharmacology & Therapeutics, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder of unknown origin and
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …

Fibrometabolism—An emerging therapeutic frontier in pulmonary fibrosis

B Selvarajah, I Azuelos, D Anastasiou… - Science Signaling, 2021 - science.org
Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …

Connective tissue growth factor in idiopathic pulmonary fibrosis: breaking the bridge

WI Effendi, T Nagano - International Journal of Molecular Sciences, 2022 - mdpi.com
CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …

Metabolic reprogramming of pulmonary fibrosis

J Li, X Zhai, X Sun, S Cao, Q Yuan… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …

[HTML][HTML] Transcriptional analysis of lung fibroblasts identifies PIM1 signaling as a driver of aging-associated persistent fibrosis

TX Pham, J Lee, J Guan, N Caporarello, JA Meridew… - JCI insight, 2022 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is an aging-associated disease characterized by
myofibroblast accumulation and progressive lung scarring. To identify transcriptional gene …

Glycolysis Reprogramming in Idiopathic Pulmonary Fibrosis: Unveiling the Mystery of Lactate in the Lung

P Yan, J Liu, Z Li, J Wang, Z Zhu, L Wang… - International Journal of …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized
by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence …

Recapitulating idiopathic pulmonary fibrosis related alveolar epithelial dysfunction in a human iPSC‐derived air‐liquid interface model

E Schruf, V Schroeder, HQ Le… - The FASEB …, 2020 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fatal disease of unknown cause that is characterized
by progressive fibrotic lung remodeling. An abnormal emergence of airway epithelial‐like …

An optical pH-sensor integrated microfluidic platform multilayered with bacterial cellulose and gelatin methacrylate to mimic drug-induced lung injury

E Saygili, U Devamoglu, E Bayir… - Journal of Industrial and …, 2023 - Elsevier
Drug-induced lung injury leading to pulmonary fibrosis is an interstitial lung pathology
destructing the architecture of lung. Although animal models have been used to understand …