Idiopathic pulmonary fibrosis (IPF) is a condition which affects mainly older adults, that
suggests mitochondrial dysfunction and oxidative stress, which follow cells senescence, and …

Idiopathic pulmonary fibrosis (IPF) represents a chronic progressive fibrotic interstitial lung
disease of unknown cause with an ominous prognosis. It remains an unprecedent clinical …

Background We have previously reported arterial remodelling in patients with idiopathic
pulmonary fibrosis (IPF) and suggested that endothelial-to-mesenchymal transition (EndMT) …

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic
pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key …

The receptor for advanced glycation end product (RAGE) is a transmembrane receptor
highly expressed in type 1 pneumocytes of healthy lungs. RAGE is considered to play a …

Fibrosis regardless of aetiology is characterised by persistently activated myofibroblasts that
are contractile and secrete excessive amounts of extracellular matrix molecules that leads to …

Background Circulating fibrocytes are an important source of fibroblasts and myofibroblasts,
which are involved in fibrotic processes, including systemic sclerosis (SSc). The study aimed …

Idiopathic pulmonary fibrosis (IPF) is a progressive and devastating interstitial lung disease.
The origin of myofibroblasts is still to be elucidated and the existence of epithelial …

Objectives We have studied the damage-associated molecular pattern protein S100A4 as a
driver of fibroblast activation in systemic sclerosis (SSc). Methods S100A4 protein …

Background Fibrosis and dystrophic calcification disrupting conduction tissue architecture
are histopathological lesions characterizing cardiac manifestations of neonatal lupus …