The past few years have seen enormous advances in genotyping technology, including
chips that accommodate in excess of 1 million SNP assays. In addition, the cost per …

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry
(MS) has developed during the past decade into a versatile tool for biopolymer analysis. The …

Teleosts comprise more than half of all vertebrate species and have adapted to a variety of
marine and freshwater habitats. Their genome evolution and diversification are important …

Alcoholism is a complex disease with both genetic and environmental risk factors. To identify
genes that affect the risk for alcoholism, we systematically ascertained and carefully …

Antigen presentation to T cells by MHC molecules is essential for adaptive immune
responses. To determine the exact position of a gene affecting expression of MHC …

Detection of minor, genetically distinct subpopulations within tumors is a key challenge in
cancer genomics. Here we report STAR-FISH (specific-to-allele PCR–FISH), a novel method …

Context Chromosome 1q42 is among several genomic regions showing replicated evidence
of linkage with schizophrenia, but the specific susceptibility mechanisms underlying this …

The onset of flowering is an important adaptive trait in plants. The small ephemeral species
Arabidopsis thaliana grows under a wide range of temperature and day-length conditions …

Recombination during meiosis shapes the complement of alleles segregating in the progeny
of hybrids, and has important consequences for phenotypic variation. We examined allele …

We report here an approach for gene expression analysis by combining competitive PCR
and matrix-assisted laser desorption ionization time-of-flight MS. A DNA standard is …