40 years after the registration of acyclovir: do we need new anti-herpetic drugs?

A Majewska, B Mlynarczyk-Bonikowska - International journal of …, 2022 - mdpi.com
Herpes simplex virus types 1 and 2 HSV1 and 2, namely varicella-zoster VZV and
cytomegalovirus CMV, are among the most common pathogens worldwide. They remain in …

[HTML][HTML] Clinical management of herpes simplex virus infections: past, present, and future

R Whitley, J Baines - F1000Research, 2018 - ncbi.nlm.nih.gov
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human
population. Most commonly, virus replication is limited to the epithelia and establishes …

Viral infections

JC Sterling - Rook's Textbook of Dermatology, Ninth Edition, 2016 - Wiley Online Library
Skin disease due to viruses may be a primary infection of the epidermis or may arise
secondary to systemic infection. Depending on the virus, the effects may be necrotic damage …

Herpes simplex viruses

RJ Whitley, DW Kimberlin, B Roizman - Clinical Infectious Diseases, 1998 - JSTOR
Herpes simplex virus (HSV) infections of humans were first documented in ancient Greece.
Greek scholars, particularly Hippocrates, used the word" herpes," meaning to creep or crawl …

Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives

HH Schalkwijk, R Snoeck, G Andrei - Biochemical Pharmacology, 2022 - Elsevier
Herpes simplex viruses (HSV), the causative agents of recurrent orofacial and anogenital
infections, can cause significant morbidity and mortality in both immunocompetent and …

Current concepts for genital herpes simplex virus infection: diagnostics and pathogenesis of genital tract shedding

C Johnston, L Corey - Clinical microbiology reviews, 2016 - Am Soc Microbiol
SUMMARY Herpes simplex virus 2 (HSV-2) is a DNA virus that is efficiently transmitted
through intimate genital tract contact and causes persistent infection that cannot be …

Antiviral therapies for herpesviruses: current agents and new directions

CL Poole, SH James - Clinical therapeutics, 2018 - Elsevier
Purpose The objective of this review was to summarize the recent literature describing the
current burden of disease due to herpesviruses in the antiviral and transplant era; describe …

Antiviral resistance in herpes simplex virus and varicella-zoster virus infections: diagnosis and management

J Piret, G Boivin - Current opinion in infectious diseases, 2016 - journals.lww.com
Antiviral resistance in herpes simplex virus and varicella-z... : Current Opinion in Infectious
Diseases Antiviral resistance in herpes simplex virus and varicella-zoster virus infections …

Current antivirals and novel botanical molecules interfering with herpes simplex virus infection

DM Álvarez, E Castillo, LF Duarte, J Arriagada… - Frontiers in …, 2020 - frontiersin.org
Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent within the
human population and are characterized by lifelong infections and sporadic recurrences …

The unique microbiome and innate immunity during pregnancy

C Mei, W Yang, X Wei, K Wu, D Huang - Frontiers in immunology, 2019 - frontiersin.org
A successful pregnancy depends on not only the tolerance of the fetal immune system by the
mother but also resistance against the threat of hazardous microorganisms. Infection with …