Halogenated antimicrobial agents to combat drug-resistant pathogens
Antimicrobial resistance presents us with a potential global crisis as it undermines the
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
abilities of conventional antibiotics to combat pathogenic microbes. The history of …
Synthesis, characterization and molecular docking studies of substituted 4-coumarinylpyrano [2, 3-c] pyrazole derivatives as potent antibacterial and anti-inflammatory …
BM Chougala, S Samundeeswari, M Holiyachi… - European journal of …, 2017 - Elsevier
A green, eco-friendly and efficient protocol has been developed and synthesized a series of
coumarin based pyrano [2, 3-c] pyrazole derivatives (3) by multi-component reaction (MCR) …
coumarin based pyrano [2, 3-c] pyrazole derivatives (3) by multi-component reaction (MCR) …
[HTML][HTML] Antibacterial and molecular docking studies of newly synthesized nucleosides and Schiff bases derived from sulfadimidines
HH Amer, EH Eldrehmy, SM Abdel-Hafez… - Scientific reports, 2021 - nature.com
A new series of nucleosides, moieties, and Schiff bases were synthesized from
sulfadimidine. Infrared (IR), 1HNMR, 13C NMR, and mass spectrometry techniques and …
sulfadimidine. Infrared (IR), 1HNMR, 13C NMR, and mass spectrometry techniques and …
Microwave-assisted synthesis, computational studies and antibacterial/anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid
RR Chavan, KM Hosamani - Royal Society open …, 2018 - royalsocietypublishing.org
An efficient, high-yield and rapid synthesis of (E)-1, 5-dimethyl-4-((2-((substituted-2-oxo-2H-
chromen-4-yl) methoxy) naphthalen-1-yl) methyleneamino)-2-phenyl-1, 2-dihydropyrazol-3 …
chromen-4-yl) methoxy) naphthalen-1-yl) methyleneamino)-2-phenyl-1, 2-dihydropyrazol-3 …
Challenging the anticolorectal cancer capacity of quinoxaline-based scaffold via triazole ligation unveiled new efficient dual VEGFR-2/MAO-B inhibitors
Monoamine oxidases (MAOs) and vascular endothelial growth factor receptor-2 (VEGFR-2)
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
are promoters of colorectal cancer (CRC) and central signaling nodes in epithelial …
[HTML][HTML] Anticancer activity, spectroscopic and molecular docking of some new synthesized sugar hydrazones, Arylidene and α-Aminophosphonate derivatives
In this work, we design and then synthesis of new derivatives of nucleosides, oxadiazoline
derivatives containing acetylated sugars and α-aminophosphonate derivatives. The …
derivatives containing acetylated sugars and α-aminophosphonate derivatives. The …
Exploration of Nitroaromatic Antibiotics via Sanger's Reagent: Synthesis, In Silico, and Antimicrobial Evaluation
Facile synthesis of molecular hybrids containing a 2, 4-dinitrophenyl moiety was achieved
via nucleophilic aromatic substitution of the fluoride anion of Sanger's reagent (2, 4 …
via nucleophilic aromatic substitution of the fluoride anion of Sanger's reagent (2, 4 …
Halting colorectal cancer metastasis via novel dual nanomolar MMP-9/MAO-A quinoxaline-based inhibitors; design, synthesis, and evaluation
MS Ayoup, MM Abu-Serie, LF Awad, M Teleb… - European Journal of …, 2021 - Elsevier
Abstract Matrix metalloproteinase-9 (MMP-9) and monoamine oxidase-A (MAO-A) are
central signaling nodes in CRC and promotors of distant metastasis associated with high …
central signaling nodes in CRC and promotors of distant metastasis associated with high …
Extensive study of DFT-quantum calculations based QSAR modeling of fused 1, 2, 4-triazine derivatives revealed potent CYP1A1 inhibitors
HEA Ahmed, A Amer, SA Senior, S Ihmaid… - Journal of …, 2022 - World Scientific
In a continuing effort for our research group, we identify new active 1, 2, 4-triazine
derivatives as novel cancer preventive agents that target CYP1A1 activity, through the …
derivatives as novel cancer preventive agents that target CYP1A1 activity, through the …
Prodrugs of sulfacetamide: Synthesis, X-ray structure, Hirshfeld analysis, antibacterial assessment, and docking studies
New prodrugs of sulfacetamide as azo compounds were synthesized and have been
evidenced through elemental and spectral analyses. Their synthesis were carried out by …
evidenced through elemental and spectral analyses. Their synthesis were carried out by …