Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?
MC Chappell - American Journal of Physiology-Heart and …, 2016 - journals.physiology.org
The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …
regulation of blood pressure through peripheral and central mechanisms. Indeed …
Mass spectrometry imaging of biomolecular information
B Spengler - Analytical chemistry, 2015 - ACS Publications
Mass spectrometry imaging (MSI) has gone through a significant change over the last 3
years, the time span of this review. The predominant mass spectrometric method in …
years, the time span of this review. The predominant mass spectrometric method in …
Mass spectrometry imaging in drug development
Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
Severe acute respiratory syndrome coronavirus 2, COVID-19, and the renin-angiotensin system: pressing needs and best research practices
The coronavirus disease 2019 (COVID-19) pandemic is associated with significant morbidity
and mortality throughout the world, predominantly due to lung and cardiovascular injury. The …
and mortality throughout the world, predominantly due to lung and cardiovascular injury. The …
[HTML][HTML] Diagnosis of bladder cancer and prediction of survival by urinary metabolomics
Bladder cancer (BC) is a common cancer but diagnostic modalities, such as cystoscopy and
urinary cytology, have limitations. Here, high-performance liquid chromatography …
urinary cytology, have limitations. Here, high-performance liquid chromatography …
Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice
Angiotensin-converting enzyme 2 (ACE2) is located in several tissues and is highly
expressed in renal proximal tubules, where it degrades the vasoconstrictor angiotensin II …
expressed in renal proximal tubules, where it degrades the vasoconstrictor angiotensin II …
Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney
O Domenig, A Manzel, N Grobe, E Königshausen… - Scientific reports, 2016 - nature.com
Cardiovascular and renal pathologies are frequently associated with an activated renin-
angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor …
angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor …
MALDI mass spectrometry imaging: A cutting‐edge tool for fundamental and clinical histopathology
R Longuespée, R Casadonte… - PROTEOMICS …, 2016 - Wiley Online Library
Histopathological diagnoses have been done in the last century based on hematoxylin and
eosin staining. These methods were complemented by histochemistry, electron microscopy …
eosin staining. These methods were complemented by histochemistry, electron microscopy …
MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation
D Calligaris, DR Feldman, I Norton… - Proceedings of the …, 2015 - National Acad Sciences
We present a proof of concept study designed to support the clinical development of mass
spectrometry imaging (MSI) for the detection of pituitary tumors during surgery. We analyzed …
spectrometry imaging (MSI) for the detection of pituitary tumors during surgery. We analyzed …
Rosiglitazone Treatment of Type 2 Diabetic db/db Mice Attenuates Urinary Albumin and Angiotensin Converting Enzyme 2 Excretion
Alterations within the renal renin angiotensin system play a pivotal role in the development
and progression of cardiovascular and renal disease. Angiotensin converting enzyme 2 …
and progression of cardiovascular and renal disease. Angiotensin converting enzyme 2 …