Following repeated opioid use, some dependent individuals experience persistent cognitive
deficits that contribute to relapse of drug-taking behaviors, and one component of this …

The brain is a remarkably complex organ responsible for a wide range of functions,
including the modulation of emotional states and movement. Neuronal circuits are believed …

Adolescence is a developmental period marked by robust neural alterations and heightened
vulnerability to stress, a factor that is highly associated with increased risk for emotional …

Rationale The dynorphin (DYN)/kappa opioid receptor (KOR) system is involved in the
dysphoric properties of drugs of abuse. Given that adolescents show reduced sensitivity to …

The opioid system modulates ethanol intake and reinforcement in adult and preweanling
rodents. While adult heterogeneous rats normally do not show ethanol-mediated locomotor …

We have used highly sensitive in situ hybridization to determine opioid receptor and peptide
expression in embryonic and postnatal rat striatum, to follow the compartmentalization into …

κ-Opioid receptor stimulation attenuates psychostimulant-induced increases in extracellular
dopamine in the caudate–putamen (CPu) and nucleus accumbens of adult rats, while …

Stimulation of κ-opioid receptors in the substantia nigra pars reticulata (SNPR) increases the
locomotor activity of young rats: an effect blocked by systemic administration of a D2-like …

Adolescence is a developmental period marked by robust neural alterations and heightened
vulnerability to stress, a factor that is highly associated with increased risk for emotional …

Stimulating κ-opioid receptors in the substantia nigra pars reticulata robustly increases the
locomotor activity of preweanling rats. To determine whether nigrothalamic and nigrotectal …