Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by cytogenetic
and genomic alterations. Up to now, combination chemotherapy remains the standard …

Histone methylation is important in the regulation of genes expression, and thus its
dysregulation has been observed in various cancers. KDM5 enzymes are capable of …

Survival outcomes for relapsed/refractory pediatric acute myeloid leukemia (R/R AML)
remain dismal. Epigenetic changes can result in gene expression alterations which are …

ATP-dependent chromatin-remodeling complexes can reorganize and remodel chromatin
and thereby act as important regulator in various cellular processes. Based on considerable …

Epigenetic regulators are frequently mutated in hematological malignancies including acute
myeloid leukemia (AML). Thus, the identification and characterization of novel epigenetic …

Acute myeloid leukemia (AML) is a heterogeneous disease with a genetic, epigenetic, and
transcriptional etiology mainly presenting somatic and germline abnormalities. AML …

A growing body of evidence suggests that the histone demethylase-lysine demethylase 5
(KDM5) family is associated with drug resistance in cancer cells. However, it is still not clear …

The past decade has seen a proliferation of drugs that target epigenetic pathways. Many of
these drugs were developed to treat acute myeloid leukemia, a condition in which …