Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

The ubiquitin proteasome system (UPS) is the main system for controlled protein
degradation and a key regulator of fundamental cellular processes. The dependency of …

Neuroinflammation is a fundamental contributor to progressive neuronal damage, which
arouses a heightened interest in neurodegenerative disease therapy. Ubiquitin-specific …

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability
to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at …

Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase.
HAUSP is a protein of immense biological importance as it is involved in several cellular …

The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …

Mcl-1 is an anti-apoptotic protein of the Bcl-2 family that is essential for the survival of
multiple cell lineages and that is highly amplified in human cancer. Under physiological …

Epigenetic silencing of tumor suppressor genes (TSGs) through DNA methylation and
histone changes is a main hallmark of cancer. U biquitin-like with PHD and R ING F inger …

Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance
and differentiation. Ubiquitination and deubiquitination must occur in a timely and well …

Targeting deubiquitinating enzymes (DUBs) has emerged as a promising therapeutic
approach in several human cancers and other diseases. DUB inhibitors are exciting …