Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics
within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six …

Over the past 20 years, a new field of research, called channelopathies, investigating
diseases caused by ion channel dysfunction has emerged. Cardiac ion channels play an …

Plasmalogens (Pls) are a class of membrane phospholipids which serve a number of
essential biological functions. Deficiency of Pls is associated with common disorders such …

Alterations in cardiac impulse conduction may exert both beneficial and detrimental effects.
The assessment of ventricular conduction properties is of paramount importance both in …

Ivabradine blocks hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels,
thereby lowering the heart rate, an action that is used clinically for the treatment of heart …

T-type Ca channels are strongly expressed and important in the developing heart. In the
adult heart, these channels play a significant role in pacemaker tissues, but there is …

Background/Aims: In order to further characterize the biological traits of Dp71, HBE over
expressing two most abundantly expressed Dp71 spliced isoforms, Dp71d and Dp71f, were …

The importance of lysosomes in cardiac physiology and pathology is well established, and
evidence for roles in calcium signaling is emerging. We describe a label-free proteomics …

The importance of lysosomes in cardiac physiology and pathology are well established, and
evidence for roles in calcium signalling are emerging. We describe a label-free proteomics …

Lysosomes are responsible for the degradation of intracellular and extracellular
macromolecules. They also play roles in signalling relevant to cardiac function and cardiac …