Functions of vertebrate ferlins
AV Bulankina, S Thoms - Cells, 2020 - mdpi.com
Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics
within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six …
within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six …
[HTML][HTML] Cardiac voltage-gated calcium channel macromolecular complexes
JS Rougier, H Abriel - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2016 - Elsevier
Over the past 20 years, a new field of research, called channelopathies, investigating
diseases caused by ion channel dysfunction has emerged. Cardiac ion channels play an …
diseases caused by ion channel dysfunction has emerged. Cardiac ion channels play an …
Oral batyl alcohol supplementation rescues decreased cardiac conduction in ether phospholipid‐deficient mice
H Todt, F Dorninger, PJ Rothauer… - Journal of Inherited …, 2020 - Wiley Online Library
Plasmalogens (Pls) are a class of membrane phospholipids which serve a number of
essential biological functions. Deficiency of Pls is associated with common disorders such …
essential biological functions. Deficiency of Pls is associated with common disorders such …
[HTML][HTML] Modulation of cardiac ventricular conduction: Impact on QRS duration, amplitude and dispersion
V Berger, L Gabriel, E Lilliu, B Hackl… - European Journal of …, 2023 - Elsevier
Alterations in cardiac impulse conduction may exert both beneficial and detrimental effects.
The assessment of ventricular conduction properties is of paramount importance both in …
The assessment of ventricular conduction properties is of paramount importance both in …
[HTML][HTML] The bradycardic agent ivabradine decreases conduction velocity in the AV node and in the ventricles in-vivo
D Amstetter, F Badt, L Rubi, RE Bittner, J Ebner… - European Journal of …, 2021 - Elsevier
Ivabradine blocks hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels,
thereby lowering the heart rate, an action that is used clinically for the treatment of heart …
thereby lowering the heart rate, an action that is used clinically for the treatment of heart …
Evidence for a physiological role of T-type Ca channels in ventricular cardiomyocytes of adult mice
J Marksteiner, J Ebner, I Salzer, E Lilliu, B Hackl… - Membranes, 2022 - mdpi.com
T-type Ca channels are strongly expressed and important in the developing heart. In the
adult heart, these channels play a significant role in pacemaker tissues, but there is …
adult heart, these channels play a significant role in pacemaker tissues, but there is …
[HTML][HTML] Altered biological properties in Dp71 over-expressing HBE cells
S Tan, S Zhao, Z Chen, Q Ma, W Wang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: In order to further characterize the biological traits of Dp71, HBE over
expressing two most abundantly expressed Dp71 spliced isoforms, Dp71d and Dp71f, were …
expressing two most abundantly expressed Dp71 spliced isoforms, Dp71d and Dp71f, were …
A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue
The importance of lysosomes in cardiac physiology and pathology is well established, and
evidence for roles in calcium signaling is emerging. We describe a label-free proteomics …
evidence for roles in calcium signaling is emerging. We describe a label-free proteomics …
Cardiac Atrial Compartmentalisation Proteomics: A Modified Density Gradient Method to Analyse Endo-lysosomal Proteins
The importance of lysosomes in cardiac physiology and pathology are well established, and
evidence for roles in calcium signalling are emerging. We describe a label-free proteomics …
evidence for roles in calcium signalling are emerging. We describe a label-free proteomics …
Atrial Fibrillation: unravelling the significance of lysosomes in atria under normal and pathological conditions
RTP Ayagama - 2021 - ora.ox.ac.uk
Lysosomes are responsible for the degradation of intracellular and extracellular
macromolecules. They also play roles in signalling relevant to cardiac function and cardiac …
macromolecules. They also play roles in signalling relevant to cardiac function and cardiac …