B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

CD4+ CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and,
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …

Abstract Interleukin-10 (IL-10)-producing regulatory B (Breg) cells suppress autoimmune
disease, and increased numbers of Breg cells prevent host defense to infection and promote …

Regulatory B cells control inflammation and autoimmunity in mice, including the recently
identified IL-10–competent B10 cell subset that represents 1% to 3% of spleen B cells. In this …

The immunosuppressive function of regulatory B cells has been shown in several murine
models of chronic inflammation, including collagen-induced arthritis, inflammatory bowel …

Transforming growth factor β (TGF-β) plays an important role in tumor initiation and
progression, functioning as both a suppressor and a promoter. The mechanisms underlying …

B cells are essential for humoral immunity, but the role that they have in regulating CD4+ T
cell responses remains controversial. However, new data showing that the transient …

T cell Ig domain and mucin domain protein 1 (TIM-1) is a costimulatory molecule that
regulates immune responses by modulating CD4+ T cell effector differentiation. However …

Abstract IL-10–producing B cells, also known as regulatory B cells (Bregs), play a key role in
controlling autoimmunity. In this study, we report that chimeric mice specifically lacking IL-10 …

OBJECTIVE The safety of dendritic cells to selectively suppress autoimmunity, especially in
type 1 diabetes, has never been ascertained. We investigated the safety of autologous …