The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …

RNA‐binding proteins (RBPs) mediate the localization, stability, and translation of the target
transcripts and fine‐tune the physiological functions of the proteins encoded. The insulin …

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …

IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding
proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that …

The human insulin-like growth factor 2 (IGF2) mRNA binding protein family (IMPs/IGF2BPs)
is involved in a spectrum of biological processes, including development, tumorigenesis …

Cancer stem cells (CSCs) can drive tumor growth, and their maintenance may rely on post-
transcriptional regulation of gene expression, including that mediated by microRNAs …

Hypoxic ischemia (HI) is an acute brain threat across all age groups. Therapeutic
hypothermia ameliorates resulting injury in neonates but its side effects prevent routine use …

HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …

Rationale: Glioma is the most common primary malignant tumor of human central nervous
system, and its rich vascular characteristics make anti-angiogenic therapy become a …

The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2 is
amplified and overexpressed in many human cancers, accompanied by a poorer prognosis …