Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …

The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Survival of multicellular organisms depends on their ability to fight infection, metabolize
nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory …

Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols
through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules …

Atherosclerosis treatments by gene regulation are garnering attention, yet delivery of gene
cargoes to atherosclerotic plaques remains inefficient. Here, we demonstrate that assembly …

Purpose Methylation of sperm DNA is impaired in many infertile men potentially adversely
effecting reproductive outcomes. In somatic cells oxidative damage to DNA and …

Globally, cardiovascular diseases (CVDs) are the number one cause of mortality.
Approximately 18 million people died from CVDs in 2015, representing more than 30% of all …

Epoxygenated fatty acids (EpFAs), which are lipid mediators produced by cytochrome P450
epoxygenases from polyunsaturated fatty acids, are important signaling molecules known to …

Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially
genotoxic—epoxides to the corresponding less reactive vicinal diols, which explains the …