Uveal melanoma is an aggressive malignancy that originates from melanocytes in the eye.
Even if the primary tumor has been successfully treated with radiation or surgery, up to half …

In addition to the contribution of cancer cells, the solid tumor microenvironment (TME) has a
critical role in determining tumor expansion, antitumor immunity, and the response to …

Immune checkpoint therapy (ICT) has transformed cancer treatment in recent years;
however, treatment response is not uniform across tumor types. The tumor immune …

Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapies including single-
agent immunotherapy and has a dense desmoplastic stroma, and most patients present with …

Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by a
paucity of tumor-proximal CD8+ T cells and resistance to immunotherapeutic interventions …

A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-
differentiation into the squamous lineage during disease progression. Here, we investigated …

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the
third leading cause of cancer-related mortality in the United States. Although important …

Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of
novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank …