Mechanistic target of rapamycin (MTOR) plays a critical role in the regulation of cell growth
and in the response to energy state changes. Drugs inhibiting MTOR are increasingly used …

AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-
kinase (PI3K)/protein kinase B (PKB) signaling, are involved in regulating cell cycle …

Drugs currently approved to coat stents used in percutaneous coronary interventions do not
discriminate between proliferating vascular smooth muscle cells (VSMCs) and endothelial …

Background—Endovascular treatment of intracranial aneurysms is safe and effective but too
often is followed by recurrences. Gene therapy may improve healing after embolization, and …

Cardiovascular disease represents a major clinical problem affecting a significant proportion
of the world's population and remains the main cause of death in the UK. The majority of …

Cardiomyocyte hypertrophy and apoptosis have been implicated in the loss of contractile
function during heart failure (HF). Moreover, patients with HF have been shown to exhibit …

We have evaluated if ultrasound imaging (US) and various commercially available contrast
microbubbles can serve as a non‐invasive systemically administered delivery vehicle for …

Peroxisome proliferator-activated receptor (PPAR) α, the molecular target for fibrates used to
treat dyslipidemia, exerts pleiotropic effects on vascular cells. In vascular smooth muscle …

The serine-threonine kinase Akt/PKB mediates stimuli from different classes of
cardiomyocyte receptors, including the growth hormone/insulin like growth factor and the β …

Self-renewal, proliferation and differentiation properties of stem cells are controlled by key
transcription factors. However, their activity is modulated by chromatin remodeling factors …