Sarcopenia, characterized by loss of skeletal muscle mass, quality, and strength, has
become a common hallmark of ageing and many chronic diseases. Diabetes mellitus …

Natural killer (NK) cells play critical roles in protection against hematological malignancies
but can acquire a dysfunctional state, which limits antitumor immunity. However, the …

Insulin resistance (IR) is a shared pathological condition among type 2 diabetes, obesity,
cardiovascular disease, and other metabolic disorders. It is growing significantly all over the …

This study aimed to investigate the effect of timosaponin B-II (TB-II) on palmitate (PA)-
induced insulin resistance and inflammation in HepG2 cells, and probe the potential …

Background. Oxidative stress, inflammation and cardiac apoptosis were closely involved in
doxorubicin (DOX)‐induced cardiac injury. Piperine has been reported to suppress …

Peroxisome proliferator-activated receptor gamma (PPARγ) participates in lipogenesis in
rats, goats, and humans. However, the exact mechanism of PPARγ regulation on milk fat …

Tea seed saponins (TSS) are oleanolane‐type pentacyclic triterpenoid saponin mixtures
with various pharmacological effects. We aimed to explore the effects of a total of 4 weeks …

Background: Chronic diseases, such as obesity and cancer, have high prevalence rates.
Both diseases have hyperinsulinemia, hyperglycemia, high levels of IGF-1 and inflammatory …

Astragaloside IV is a monomer isolated from Astragalus membranaceus (Fisch.) Bunge,
which is one of the most widely used plant-derived drugs in traditional Chinese medicine for …

Ampelopsin (APL), a major bioactive constituent of Ampelopsis grossedentata, exerts a
number of biological effects. Here, we explored the anti-diabetic activity of APL and …