The ASK1-signalosome→ p38 MAPK and SAPK/JNK signaling networks promote
senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to …

Cellular senescence is a major contributor to age-related diseases in humans; however, it
also has a beneficial role in physiological and pathological processes, including wound …

Muscle regeneration is sustained by infiltrating macrophages and the consequent activation
of satellite cells,,–. Macrophages and satellite cells communicate in different ways,,,–, but …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Background Ageing, chronic diseases, prolonged inactivity, and inadequate nutrition pose a
severe threat to skeletal muscle health and function. To date, experimental evidence …

Skeletal muscle is the dominant organ system in locomotion and energy metabolism.
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …

Inflammation is an important contributor to the pathology of diseases implicated in skeletal
muscle dysfunction. A number of diseases and disorders including inflammatory myopathies …

Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of
muscular mass and the contractile capacity of the skeletal muscle as a consequence of …

Sarcopenia is one of the leading causes of disability in the elderly. Despite the growing
prevalence of sarcopenia, the molecular mechanisms that control aging-related changes in …

The increasing prevalence of older-age people in our society represents the culmination of
centuries of medical, scientific, and social endeavors. At least in Western society, now …