Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Obesity is characterized by increased storage of fatty acids in an expanded adipose tissue
mass and is closely associated with the development of insulin resistance in peripheral …

The aim of this narrative review is to provide current evidence for the interaction between
obesity, metabolic syndrome (MS) and reproductive axis. Gonadotropin-releasing hormone …

Over the past decade and a half it has become increasingly clear that adipose tissue is a
much more complex organ than was initially considered and that its metabolic functions …

Resistin is a novel adipocyte-secreted hormone proposed to link obesity with diabetes.
Studies in mice have revealed conflicting data however, and the physiological role of …

Obesity and noninsulin‐dependent diabetes mellitus are globally epidemic. Insulin
resistance is a major contributor to the pathogenesis of type II diabetes and plays a role in …

This is the ninth update of the human obesity gene map, incorporating published results
through October 2002 and continuing the previous format. Evidence from single‐gene …

Insulin resistance in skeletal muscle plays a major role in the development of type 2
diabetes and may be causally associated with increases in intramuscular fatty acid …

With the completion of the human genome project, attention is now rapidly shifting towards
the study of individual genetic variation. The most abundant source of genetic variation in …

Body weight is a quantitative trait with significant heritability in humans. To identify potential
genetic contributors to this phenotype, we resequenced the coding exons and splice …