Single-molecule protein sensing in a nanopore: a tutorial

N Varongchayakul, J Song, A Meller… - Chemical Society …, 2018 - pubs.rsc.org
Proteins are the structural elements and machinery of cells responsible for a functioning
biological architecture and homeostasis. Advances in nanotechnology are catalyzing key …

Plasmonic‐nanopore biosensors for superior single‐molecule detection

JD Spitzberg, A Zrehen, XF van Kooten… - Advanced …, 2019 - Wiley Online Library
Plasmonic and nanopore sensors have separately received much attention for achieving
single‐molecule precision. A plasmonic “hotspot” confines and enhances optical excitation …

Electroosmosis in nanopores: computational methods and technological applications

A Gubbiotti, M Baldelli, G Di Muccio… - … in Physics: X, 2022 - Taylor & Francis
Electroosmosis is a fascinating effect where liquid motion is induced by an applied electric
field. Counter ions accumulate in the vicinity of charged surfaces, triggering a coupling …

Controlling electroosmosis in nanopores without altering the nanopore sensing region

M Baldelli, G Di Muccio, A Sauciuc… - Advanced …, 2024 - Wiley Online Library
Nanopores are powerful tools for single‐molecule sensing of biomolecules and
nanoparticles. The signal coming from the molecule to be analyzed strongly depends on its …

Solid-state and polymer nanopores for protein sensing: A review

N Meyer, I Abrao-Nemeir, JM Janot, J Torrent… - Advances in colloid and …, 2021 - Elsevier
In two decades, the solid state and polymer nanopores became attractive method for the
protein sensing with high specificity and sensitivity. They also allow the characterization of …

Recent progress of biosensors for the detection of lung cancer markers

S Chen, M Li, T Weng, D Wang, J Geng - Journal of Materials …, 2023 - pubs.rsc.org
Lung cancer is one of the most common cancers worldwide and the leading cause of death.
Early screening of lung cancer is exceptionally essential for later treatment. Abnormal lung …

Differential enzyme flexibility probed using solid-state nanopores

R Hu, JV Rodrigues, P Waduge, H Yamazaki… - ACS …, 2018 - ACS Publications
Enzymes and motor proteins are dynamic macromolecules that coexist in a number of
conformations of similar energies. Protein function is usually accompanied by a change in …

Four aspects about solid‐state nanopores for protein sensing: fabrication, sensitivity, selectivity, and durability

R Hu, X Tong, Q Zhao - Advanced healthcare materials, 2020 - Wiley Online Library
Solid‐state nanopores are a mimic of innate biological nanopores embedded on lipid
membranes. They are fabricated on thin suspended layers of synthetic materials that provide …

Protein sequencing via nanopore based devices: a nanofluidics perspective

M Chinappi, F Cecconi - Journal of Physics: Condensed Matter, 2018 - iopscience.iop.org
Proteins perform a huge number of central functions in living organisms, thus all the new
techniques allowing their precise, fast and accurate characterization at single-molecule level …

Single-molecule electrical and spectroscopic profiling protein allostery using a gold plasmonic nanopore

W Li, J Zhou, Q Lan, XL Ding, XT Pan, SA Ahmed… - Nano Letters, 2023 - ACS Publications
Direct structural and dynamic characterization of protein conformers in solution is highly
desirable but currently impractical. Herein, we developed a single molecule gold plasmonic …