Ataxia-telangiectasia (AT) is caused by absence of the catalytic activity of ATM, a protein
kinase that plays a central role in the DNA damage response, many branches of cellular …

Introduction Ataxia telangiectasia (AT) is a life-limiting autosomal recessive disease
characterized by cerebellar degeneration, ocular telangiectasias, and sinopulmonary …

The autosomal recessive disorder Ataxia-Telangiectasia is caused by a dysfunction of the
stress response protein, ATM. In the nucleus of proliferating cells, ATM senses DNA double …

The ataxia-telangiectasia mutated (ATM) protein kinase is, as the name implies, mutated in
the human genetic disorder ataxia-telangiectasia (AT). This protein has its “finger in many …

Aging is a gradual and irreversible natural process. With aging, the body experiences a
functional decline, and the effects amplify the vulnerability to a range of age-related …

Ataxia Telangiectasia (AT) is a rare disorder caused by mutations in the ATM gene and
results in progressive neurodegeneration for reasons that remain poorly understood. In …

Introduction The last decade has witnessed major breakthroughs in identifying novel genetic
causes of hereditary ataxias, deepening our understanding of disease mechanisms, and …

Several scientific themes are reviewed in the context of the 75-year period relevant to this
special platinum issue of Radiation Research. Two criteria have been considered in …