Isatin (1 H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in
humans and different plants. The isatin nucleus and its derivatives are owed the attention of …

Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to
anticancer agents represents one of the major obstacles for the effective cancer treatment …

The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a–e
and 7a–i) was designed and synthesised. The anticancer activity for compounds (5b–d, 7a …

Breast cancer, an epithelial malignant tumor that occurs in the terminal ducts of the breast, is
the most common female malignancy. Currently, approximately 70%–80% of breast cancer …

In drug discovery, the hybridization of bioactive pharmacophores is a powerful tool for
targeting enzymes involved in cancer and microbial cell growth. A combination of 1, 3, 4 …

Breast cancer (BC) is a global health risk for women and has a high prevalence rate. The
drug resistance, recurrence, and metastasis of BC affect patient prognosis, thus posing a …

The emergence of the severe acute respiratory syndrome 2 (SARS-CoV-2) as a global threat
has driven the urgent need for the identification of bioactive molecules capable of controlling …

Isatin has garnered significant interest due to its wide range of pharmacological activities,
including anti-inflammatory, anti-HIV, anticancer, antioxidant, antimicrobial, and antifungal …

The purpose of this study is to underline the progression and development of research
regarding oxygen-containing heterocycles, as well as to highlight the contribution that some …