[HTML][HTML] Podophyllotoxin: Recent Advances in the Development of Hybridization Strategies to Enhance Its Antitumoral Profile
C Miranda-Vera, ÁP Hernández, P García-García… - Pharmaceutics, 2023 - mdpi.com
Podophyllotoxin is a naturally occurring cyclolignan isolated from rhizomes of Podophyllum
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …
sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more …
[HTML][HTML] Bioactive prenyl-and terpenyl-quinones/hydroquinones of marine origin
The sea is a rich source of biological active compounds, among which terpenyl-quinones/
hydroquinones constitute a family of secondary metabolites with diverse pharmacological …
hydroquinones constitute a family of secondary metabolites with diverse pharmacological …
Discovery of Anticancer Hybrid Molecules by Supervised Machine Learning Models and in Vitro Validation in Drug Resistant Chronic Myeloid Leukemia Cells
The concept of hybrid drugs for targeting multiple aberrant pathways of cancer, by
combining the key pharmacophores of clinically approved single-targeted drugs, has …
combining the key pharmacophores of clinically approved single-targeted drugs, has …
[HTML][HTML] Enhancement of tumor cell immunogenicity and antitumor properties derived from platinum-conjugated iron nanoparticles
ÁP Hernández, L Iglesias-Anciones… - Cancers, 2023 - mdpi.com
Simple Summary The immune system has been shown to play a critical role in controlling
tumor development. Therefore, therapeutic strategies based on targeting tumors from this …
tumor development. Therefore, therapeutic strategies based on targeting tumors from this …
[HTML][HTML] A new host-targeted antiviral cyclolignan (SAU-22.107) for Dengue Virus infection in cell cultures. Potential action mechanisms based on cell imaging
Dengue virus (DENV) infection is the most arbovirosis in the world. However, medications
have not been approved for its treatment. Drug discovery based on the host-targeted …
have not been approved for its treatment. Drug discovery based on the host-targeted …
[HTML][HTML] Improving Properties of Podophyllic Aldehyde-Derived Cyclolignans: Design, Synthesis and Evaluation of Novel Lignohydroquinones, Dual-Selective Hybrids …
New lignohydroquinone conjugates (L-HQs) were designed and synthesized using the
hybridization strategy, and evaluated as cytotoxics against several cancer cell lines. The L …
hybridization strategy, and evaluated as cytotoxics against several cancer cell lines. The L …
Pterostilbene-Isothiocyanate Inhibits Proliferation of Human MG-63 Osteosarcoma Cells via Abrogating β-Catenin/TCF-4 Interaction─ A Mechanistic Insight
Osteosarcoma, a highly metastasizing bone neoplasm, is a leading cause of death and
disability in children and adolescents worldwide. Osteosarcoma is only suboptimally …
disability in children and adolescents worldwide. Osteosarcoma is only suboptimally …
[HTML][HTML] A novel cytotoxic conjugate derived from the natural product podophyllotoxin as a direct-target protein dual inhibitor
Natural products are the ideal basis for the design of novel efficient molecular entities.
Podophyllotoxin, a naturally occurring cyclolignan, is an example of natural product which …
Podophyllotoxin, a naturally occurring cyclolignan, is an example of natural product which …
[HTML][HTML] New antineoplastic naphthohydroquinones attached to labdane and rearranged diterpene skeletons
ÁP Hernández, P Chamorro, ML Rodríguez… - Molecules, 2021 - mdpi.com
Terpenylquinones are mixed biogenesis primary or secondary metabolites widespread in
Nature with many biological activities, including the antineoplastic cytotoxicity, that have …
Nature with many biological activities, including the antineoplastic cytotoxicity, that have …