Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Human B cells could be divided into four classical subsets based on CD27 and
immunoglobulin (Ig) D expression. Distinct from the other three well-studied subsets, CD27 …

Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …

Plasma cells (PCs) are responsible for the production of protective antibodies against
infectious agents but they also produce pathogenic antibodies in autoimmune diseases …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B cell
dysfunction, production of autoantibodies directed toward cellular and nuclear components …

Abstract Purpose of Review Our understanding on genetic basis of SLE has been advanced
through genome-wide association studies. We review recent progress in lupus genetics with …

Systemic lupus erythematosus (SLE) is an autoimmune illness marked by the loss of
immune tolerance and the production of autoantibodies against nucleic acids and other …

B cells expressing the transcription factor T-bet are found to have a protective role in viral
infections, but are also considered major players in the onset of different types of …

Efficient mechanisms of central tolerance, including receptor editing and deletion, prevent
highly self‐reactive B cell receptors (BCRs) from populating the periphery. Despite this …

Self-tolerance involves protection from self-reactive B and T cells via negative selection
during differentiation, programmed cell death, and inhibition of regulatory T cells. The …