The fourth edition of the World Health Organization (WHO) Classification of Tumours of Soft
Tissue and Bone was published in February 2013, and serves to provide an updated …

Highlights•This consensus paper provides key recommendations on the management of
epithelioid hemangioendothelioma (EHE).•Recommendations followed a consensus …

Background Activating enhancer of zeste homolog 2 (EZH2) mutations or aberrations of the
switch/sucrose non-fermentable (SWI/SNF) complex (eg, mutations or deletions of the …

The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the
sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from …

To more fully characterize the clinical and pathologic spectrum of a recently described tumor
entity of the sinonasal tract characterized by loss of nuclear expression of SMARCB1 (INI1) …

Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …

Synovial sarcoma (SS) is a malignant mesenchymal neoplasm with variable epithelial
differentiation, with a propensity to occur in young adults and which can arise at almost any …

The SWI/SNF complexes, initially identified in yeast 20 years ago, are a family of multi-
subunit complexes that use the energy of adenosine triphosphate (ATP) hydrolysis to …

A growing number of studies suggest critical tumor suppressor roles of the SWI/SNF
chromatin remodeling complex in a variety of human cancers. The recent discovery of …

Epithelioid hemangioendothelioma (EHE) is a malignant endothelial neoplasm
characterized by recurrent translocations involving chromosomal regions 1p36. 3 and 3q25 …