[HTML][HTML] Solid-state NMR spectroscopy in pharmaceutical sciences

M Li, W Xu, Y Su - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Pharmaceutical cocrystals and poorly soluble drugs

R Thakuria, A Delori, W Jones, MP Lipert, L Roy… - International journal of …, 2013 - Elsevier
In recent years cocrystal formation has emerged as a viable strategy towards improving the
solubility and bioavailability of poorly soluble drugs. In this review the success of numerous …

First-principles calculation of NMR parameters using the gauge including projector augmented wave method: a chemist's point of view

C Bonhomme, C Gervais, F Babonneau… - Chemical …, 2012 - ACS Publications
First-principles calculations of NMR parameters in solids (including the chemical shift, the
quadrupolar interaction for nuclei with spin quantum number I> 1/2, and the indirect J …

Eutectics as improved pharmaceutical materials: design, properties and characterization

S Cherukuvada, A Nangia - Chemical Communications, 2014 - pubs.rsc.org
Eutectics are a long known class of multi-component solids with important and useful
applications in daily life. In comparison to other multi-component crystalline solids, such as …

Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques

E Pindelska, A Sokal, W Kolodziejski - Advanced drug delivery reviews, 2017 - Elsevier
The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

SL Childs, N Rodríguez-Hornedo, LS Reddy… - …, 2008 - pubs.rsc.org
Four different screening techniques were used to form cocrystals of carbamazepine
containing pharmaceutically acceptable carboxylic acids. Twenty-seven unique solid …

Anion-switchable supramolecular gels for controlling pharmaceutical crystal growth

JA Foster, MOM Piepenbrock, GO Lloyd, N Clarke… - Nature …, 2010 - nature.com
We describe the use of low-molecular-weight supramolecular gels as media for the growth
of molecular crystals. Growth of a range of crystals of organic compounds, including …

A strategy for producing predicted polymorphs: catemeric carbamazepine form V

JB Arlin, LS Price, SL Price, AJ Florence - Chemical Communications, 2011 - pubs.rsc.org
A strategy for producing predicted polymorphs: catemeric carbamazepine form V - Chemical
Communications (RSC Publishing) DOI:10.1039/C1CC11634G Royal Society of Chemistry …

Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion

X Liu, M Lu, Z Guo, L Huang, X Feng, C Wu - Pharmaceutical research, 2012 - Springer
Purpose To explore in-situ forming cocrystal as a single-step, efficient method to significantly
depress the processing temperature and thus minimize the thermal degradation of heat …

NMR studies of organic polymorphs & solvates

RK Harris - Analyst, 2006 - pubs.rsc.org
This review article describes the applications of NMR to the study of polymorphs and related
forms (solvates) of organic (especially pharmaceutical) compounds, for which it is of …