Leptin is a 16 kDa protein mainly produced by adipose tissue in proportion to adipose tissue
mass. Originally thought to be a satiety factor, leptin is a pleiotropic molecule. In addition to …

HIV lipodystrophy is a heterogeneous syndrome, which has yet to be objectively defined,
comprising peripheral lipoatrophy, central fat accumulation and lipomata, along with …

Objective To identify clinical factors associated with prevalence of fat atrophy (lipoatrophy)
and fat accumulation (lipoaccumulation) in HIV-1 infected patients. Design Evaluation of HIV …

Objective: Little prospective data are published on the natural history of HIV-associated
lipodystrophy (HIVLD) in individuals beginning their first antiretroviral regimen. To …

Abstract Treatment with HIV-1 protease inhibitors (PI) is associated with a reduced incidence
or regression of Kaposi sarcoma (KS). Here we show that systemic administration of the PIs …

Objective: To estimate insulin resistance and its relationship to antiretroviral therapy (ART) in
a cohort of HIV-infected persons with comparison to HIV-seronegative controls. Design …

A lipodystrophic syndrome and metabolic abnormalities have been observed in HIV-infected
patients treated with highly active antiretroviral therapy (HAART). A murine model of …

Accelerated bone resorption leading to osteopenia and osteoporosis has been noted in
human immunodeficiency virus (HIV) seropositive, treatment-naive patients, but it may be …

Objective To achieve a better understand of the pathophysiology of HIV-related lipoatrophy,
we compared the mRNA expression of adipocytokines in fat samples from patients and …

To identify clinical factors associated with the incidence of HIV-1-associated lipoatrophy, HIV-
1-infected patients in the HIV Outpatient Study (HOPS) were prospectively evaluated for …