Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to
the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or …

Comparative genomics demonstrated that the chromosomes from bacteria and their viruses
(bacteriophages) are coevolving. This process is most evident for bacterial pathogens where …

Golden color imparted by carotenoid pigments is the eponymous feature of the human
pathogen Staphylococcus aureus. Here we demonstrate a role of this hallmark phenotype in …

Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection.
Here we report on our use of conditional gene targeting to examine the contribution of …

Streptococcus pyogenes is also known as group A Streptococcus (GAS) and is an important
human pathogen that causes considerable morbidity and mortality worldwide. The GAS …

Recent work from several laboratories has demonstrated that proteolytic mechanisms
significantly contribute to the molecular interplay between Streptococcus pyogenes, an …

The group A streptococcus (GAS)(Streptococcus pyogenes) is among the most common and
versatile of human pathogens. It is responsible for a wide spectrum of human diseases …

Most invasive bacterial infections are caused by species that more commonly colonize the
human host with minimal symptoms. Although phenotypic or genetic correlates underlying a …

Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a
central role in mammalian iron homeostasis. Here we demonstrate the endogenous …

Many human pathogens produce phenotypic variants as a means to circumvent the host
immune system and enhance survival and, as a potential consequence, exhibit increased …