Genomic and biochemical insights into the specificity of ETS transcription factors
PC Hollenhorst, LP McIntosh… - Annual review of …, 2011 - annualreviews.org
ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …
These proteins direct gene expression in diverse normal and disease states by binding to …
The role of the transcription factor Ets1 in carcinoma
J Dittmer - Seminars in cancer biology, 2015 - Elsevier
Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …
Annotation of functional variation in personal genomes using RegulomeDB
As the sequencing of healthy and disease genomes becomes more commonplace, detailed
annotation provides interpretation for individual variation responsible for normal and …
annotation provides interpretation for individual variation responsible for normal and …
Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape
DNA sequence is a major determinant of the binding specificity of transcription factors (TFs)
for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with …
for their genomic targets. However, eukaryotic cells often express, at the same time, TFs with …
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function
Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial
DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 …
DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 …
Genome‐wide analysis of ETS‐family DNA‐binding in vitro and in vivo
Members of the large ETS family of transcription factors (TFs) have highly similar DNA‐
binding domains (DBDs)—yet they have diverse functions and activities in physiology and …
binding domains (DBDs)—yet they have diverse functions and activities in physiology and …
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia
T Sanda, LN Lawton, MI Barrasa, ZP Fan… - Cancer cell, 2012 - cell.com
The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases
of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the …
of human T cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the …
ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …
Genetic determinants of co-accessible chromatin regions in activated T cells across humans
Over 90% of genetic variants associated with complex human traits map to non-coding
regions, but little is understood about how they modulate gene regulation in health and …
regions, but little is understood about how they modulate gene regulation in health and …
Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors
RNA polymerase (Pol) III transcribes many noncoding RNAs (for example, transfer RNAs)
important for translational capacity and other functions. We localized Pol III, alternative TFIIIB …
important for translational capacity and other functions. We localized Pol III, alternative TFIIIB …