Diabetes mellitus is prevalent among women of reproductive age, and many women are left
undiagnosed or untreated. Gestational diabetes has profound and enduring effects on the …

Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates
Smad and non-Smad signaling pathways and regulates expression of its target nuclear …

ABSTRACT Growth differentiation factor 11 (GDF11) is a member of the transforming growth
factor-β superfamily that has garnered significant attention due to its anti-cardiac aging …

Non-healing diabetic wounds (DW) are a serious clinical problem that remained poorly
understood. We recently found that topical application of growth differentiation factor 11 …

Myocardial fibrosis is the characteristic pathology of diabetes-induced cardiomyopathy.
Therefore, an in-depth study of cardiac heterogeneity and cell-to-cell interactions can help …

The increasing prevalence of type 2 diabetes poses a major challenge to societies
worldwide. Blood-based factors like serum proteins are in contact with every organ in the …

Background It has been documented that aerobic exercise (AE) has a positive effect on
improving cognitive function in type 2 diabetes (T2DM) patients. Here, we tried to explore …

As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C.
elegans. How the EN acquires senescence, however, is unknown. Here, we show that …

In the present study, the hypoglycemic mechanism of a homogeneous Dendrobium
huoshanense polysaccharide (GXG) was investigated using type 2 diabetic (T2D) mouse …

Prevailing insulin resistance and the resultant hyperglycemia elicits a compensatory
response from pancreatic islet beta cells (β-cells) that involves increases in β-cell function …