Fluorine, often called as “a small atom with a big ego”, 1 lies in the second row and the 17th
column in the periodic table of the chemical elements. This unique position in the periodic …

Owing to the excellent performance of fluorinated compounds in the areas of
pharmaceuticals, agrochemicals, and materials chemistry, organic chemists have made …

A transition‐metal‐free difluoromethylenation of diazo compounds that proceeds under mild
conditions has been developed and is based on the use of TMSCF2Br as the …

Transition-metal-mediated fluoroalkylation is a hot research topic in current organofluorine
chemistry. In the past five years, due to the development of new perfluoroalkylation reagents …

Impressive progress has been achieved during the past decade in the incorporation of
various fluroinecontaining groups, especially lightly fluorinated groups, into organic …

Difluoromethyl groups possess specific steric and electronic properties due to their slightly
acidic C–H bonds and the natural characteristics of fluorine atoms, which allow them to act …

A diversity-oriented and C2-selective synthesis of difluoroalkyl-substituted heteroarenes
from three fragments, N-methoxyazinium salts, difluorocarbene, and electrophilic or radical …

Metal-assisted trifluoromethylation and perfluoroalkylation reactions are probably one of the
first approaches employed to achieve fluoroalkyl-group substitutions of organic substrates …

A mild and general procedure for the difluoromethylation of organochalcogen compounds
has been accomplished via sulfoxide and selenoxide-directed [3, 3]-sigmatropic …

An efficient method for the synthesis of difluoroalkylated 2-azaspiro [4.5] decanes via copper-
catalyzed difluoroalkylation of N-benzylacrylamides with ethyl bromodifluoroacetate has …