ITCH as a potential therapeutic target in human cancers
Abstract The ITCH/AIP4 ubiquitin E3 ligase was discovered independently by two groups
searching for atrophin-1 interacting proteins and studying the genetics of mouse coat color …
searching for atrophin-1 interacting proteins and studying the genetics of mouse coat color …
Role of the ubiquitin ligase ITCH in clathrin-mediated endocytosis of the epidermal growth factor receptor
R Ayoubi, PS McPherson, A Angers - BioRxiv, 2021 - biorxiv.org
Once activated by ligand, epidermal growth factor receptor (EGFR) is endocytosed in
clathrin-coated pits. ITCH is an E3 ubiquitin ligase that interacts with and ubiquitinates …
clathrin-coated pits. ITCH is an E3 ubiquitin ligase that interacts with and ubiquitinates …