Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

The enteric nervous system (ENS) consists of thousands of small ganglia arranged in the
submucosal and myenteric plexuses, which can be negatively affected by Crohn's disease …

Gut homeostasis results from complex neuro-immune interactions aimed at triggering
stereotypical and specific programs of coordinated mucosal secretion and powerful motor …

Objectives: Ischemic tissue injury contributes to significant morbidity and mortality and is
implicated in a range of pathologic conditions, including but not limited to myocardial …

The digestive tracts of ulcerative colitis and Crohn's disease patients present with
pathophysiological processes and intestinal necrosis. This study examined the P2X7 …

The aim of this study was to evaluate the effect of ulcerative colitis on the submucosal
neurons and glial cells of the submucosal ganglia of rats. 2, 4, 6-Trinitrobenzene sulfonic …

Gastrointestinal dysmotility frequently occurs in cancer cachexia and may result from
damage to enteric innervation caused by oxidative stress, especially due to glutathione …

The P2X7 receptor participates in several intracellular events and acts with the pannexin-1
channel. This study examined the effects of probenecid (PB) and brilliant blue G (BBG) …

Background Intestinal ischemia followed by reperfusion (I/R) may occur following intestinal
obstruction. In rats, I/R in the small intestine leads to structural changes accompanied by …