The complexity and costs associated with traditional randomized, controlled trials have
increased exponentially over time, and now threaten to stifle the development of new drugs …

The electronic health record (EHR) represents a rich source of patient information,
increasingly being leveraged for cardiovascular research. Although its primary use remains …

Importance Determining the right dosage of aspirin for the secondary prevention treatment of
atherosclerotic cardiovascular disease (ASCVD) remains an unanswered and critical …

Evidence-based nutritional recommendations address the health impact of suboptimal
nutritional status. Efficacy randomized controlled trials (RCTs) have traditionally been the …

Highlights•Artificial intelligence (AI) and real-world data (RWD) are increasing used in drug
development.•Adverse event detection, trial recruitment, and drug repurposing are the most …

Background To address the obesity epidemic, there is a need for novel paradigms, including
those that address the timing of eating and sleep in relation to circadian rhythms. Electronic …

Aims To evaluate, using quantitative and qualitative approaches, published data on the
design and conduct of decentralised clinical trials (DCTs). Methods We searched MEDLINE …

In 2015, we provided an overview of the use of digital technologies in clinical trials, both as a
methodological tool and as a mechanism to deliver interventions. At that time, there was …

Background/aims: Electronic-based recruitment methods are increasingly utilized in clinical
trials to recruit and enroll research participants. The cost-effectiveness of electronic-based …

Electronic medical records (EMRs) were primarily introduced as a digital health tool in
hospitals to improve patient care, but over the past decade, research works have …