Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Composite pain biomarker signatures for objective assessment and effective treatment
Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …
Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception
LL Tan, MJ Oswald, C Heinl… - Nature …, 2019 - nature.com
In humans, gamma-band oscillations in the primary somatosensory cortex (S1) correlate
with subjective pain perception. However, functional contributions to pain and the nature of …
with subjective pain perception. However, functional contributions to pain and the nature of …
Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain
Increased low frequency cortical oscillations are observed in people with neuropathic pain,
but the cause of such elevated cortical oscillations and their impact on pain development …
but the cause of such elevated cortical oscillations and their impact on pain development …
[HTML][HTML] Inflammatory and neuropathic pain from bench to bedside: what went wrong?
RP Yezierski, P Hansson - The Journal of Pain, 2018 - Elsevier
In recent years, the disappointing history of translation in pain research has undergone
significant scrutiny. The escalation of knowledge and understanding related to presumed …
significant scrutiny. The escalation of knowledge and understanding related to presumed …
Neuroimaging of pain in animal models: a review of recent literature
JT Da Silva, DA Seminowicz - Pain reports, 2019 - journals.lww.com
Neuroimaging of pain in animals allows us to better understand mechanisms of pain
processing and modulation. In this review, we discuss recently published brain imaging …
processing and modulation. In this review, we discuss recently published brain imaging …
Electrostatic–Mechanical Synergistic In Situ Multiscale Tissue Adhesion for Sustainable Residue‐Free Bioelectronics Interfaces
Recent studies on soft adhesives have sought to deeply understand how their chemical or
mechanical structures interact strongly with living tissues. The aim is to optimally address the …
mechanical structures interact strongly with living tissues. The aim is to optimally address the …
Neurobiology of brain oscillations in acute and chronic pain
LL Tan, MJ Oswald, R Kuner - Trends in neurosciences, 2021 - cell.com
Pain is a complex perceptual phenomenon. Coordinated activity among local and distant
brain networks is a central element of the neural underpinnings of pain. Brain oscillatory …
brain networks is a central element of the neural underpinnings of pain. Brain oscillatory …
[HTML][HTML] Pain phenotypes classified by machine learning using electroencephalography features
Pain is a multidimensional experience mediated by distributed neural networks in the brain.
To study this phenomenon, EEGs were collected from 20 subjects with chronic lumbar …
To study this phenomenon, EEGs were collected from 20 subjects with chronic lumbar …