Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

For decades, scientists have been using two-dimensional cell culture platforms for high-
throughput drug screening of anticancer drugs. Growing evidence indicates that the results …

An early step of metastasis requires a complex and coordinated migration of invasive tumor
cells into the surrounding tumor microenvironment (TME), which contains extracellular …

Precision medicine approaches such as gene editing via clustered regularly interspaced
short palindromic repeat (CRISPR) and their associated protein (Cas-9) are revolutionizing …

Microfluidic platforms gain popularity in biomedical research due to their attractive inherent
features, especially in nanomaterials synthesis. This review critically evaluates the current …

Single-cell Sequencing (SCS) technologies, methods for analyzing genetic material at the
single-cell level, offer extensive insights into cellular heterogeneity. This has broadened …

With ever increasing drug resistance and emergence of new diseases, demand for new drug
development is at an unprecedented urgency. This fact has led to extensive recent efforts to …

Androgen deprivation therapy has a central role in the treatment of advanced prostate
cancer, often causing initial tumour remission before increasing independence from signal …

The need to understand human body functions, monitor disease progression, and advance
in drug development have consistently been major driving forces for medical innovations …

In contrast to traditional 2D cell cultures, both 3D models and organ-on-a-chip devices allow
the study of the physiological responses of human cells. These models reconstruct human …