Neutrophils in chronic inflammatory diseases

A Herrero-Cervera, O Soehnlein… - Cellular & molecular …, 2022 - nature.com
Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Pathogenesis of acute respiratory distress syndrome

LA Huppert, MA Matthay… - Seminars in respiratory and …, 2019 - thieme-connect.com
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure
caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical …

Neutrophils in tissue injury and repair

J Wang - Cell and tissue research, 2018 - Springer
As one of the first defenders of innate immune response, neutrophils make a rapid and
robust response against infection or harmful agents. While traditionally regarded as suicidal …

[HTML][HTML] Promoting tissue regeneration by modulating the immune system

Z Julier, AJ Park, PS Briquez, MM Martino - Acta biomaterialia, 2017 - Elsevier
The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

G Schett, MF Neurath - Nature communications, 2018 - nature.com
Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization

E Nolan, VL Bridgeman, L Ombrato, A Karoutas… - Nature cancer, 2022 - nature.com
Radiotherapy is one of the most effective approaches to achieve tumor control in cancer
patients, although healthy tissue injury due to off-target radiation exposure can occur. In this …

More friend than foe: the emerging role of neutrophils in tissue repair

M Peiseler, P Kubes - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
Neutrophils are the most abundant immune cells in humans and serve as first responders to
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …

[HTML][HTML] Understanding the role of neutrophils in acute respiratory distress syndrome

SC Yang, YF Tsai, YL Pan, TL Hwang - Biomedical Journal, 2021 - Elsevier
Acute respiratory distress syndrome (ARDS) is difficult to treat and is associated with a high
mortality rate. The most severe form of coronavirus disease 2019 (COVID-19) also leads to …

Inflammation and the intestinal barrier: leukocyte–epithelial cell interactions, cell junction remodeling, and mucosal repair

AC Luissint, CA Parkos, A Nusrat - Gastroenterology, 2016 - Elsevier
The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic,
permeable barrier allowing for selective absorption of nutrients, while restricting access to …

Apoptotic cell clearance: basic biology and therapeutic potential

IKH Poon, CD Lucas, AG Rossi… - Nature Reviews …, 2014 - nature.com
The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …