Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities

N Schneider, Y Sundaresan, P Gopalakrishnan… - Progress in retinal and …, 2022 - Elsevier
Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

Bio-inspired flexible electronics for smart E-skin

B Nie, S Liu, Q Qu, Y Zhang, M Zhao, J Liu - Acta Biomaterialia, 2022 - Elsevier
Abstract “Learning from nature” provides endless inspiration for scientists to invent new
materials and devices. Here, we review state-of-the-art technologies in flexible electronics …

Retinal microglia: Functions and diseases

W Fan, W Huang, J Chen, N Li, L Mao, S Hou - Immunology, 2022 - Wiley Online Library
Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …

[HTML][HTML] Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

J Ribeiro, CA Procyk, EL West, M O'Hara-Wright… - Cell reports, 2021 - cell.com
Age-related macular degeneration and other macular diseases result in the loss of light-
sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor …

Chemical reprogramming for cell fate manipulation: methods, applications, and perspectives

J Wang, S Sun, H Deng - Cell Stem Cell, 2023 - cell.com
Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …

Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies

K Kruczek, A Swaroop - Stem Cells, 2020 - academic.oup.com
Retinal diseases constitute a genetically and phenotypically diverse group of clinical
conditions leading to vision impairment or blindness with limited treatment options …

Nanotube‐like processes facilitate material transfer between photoreceptors

AA Kalargyrou, M Basche, A Hare, EL West… - EMBO …, 2021 - embopress.org
Neuronal communication is typically mediated via synapses and gap junctions. New forms
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs) …

[HTML][HTML] Primary cilia biogenesis and associated retinal ciliopathies

HY Chen, RA Kelley, T Li, A Swaroop - Seminars in cell & developmental …, 2021 - Elsevier
The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming

Á Herrero-Navarro, L Puche-Aroca, V Moreno-Juan… - Science …, 2021 - science.org
Neural cell diversity is essential to endow distinct brain regions with specific functions.
During development, progenitors within these regions are characterized by specific gene …

A phase I clinical trial of human embryonic stem cell‐derived retinal pigment epithelial cells for early‐stage Stargardt macular degeneration: 5‐years' follow‐up

SY Li, Y Liu, L Wang, F Wang, TT Zhao, QY Li… - Cell …, 2021 - Wiley Online Library
Objectives To evaluate the long‐term biosafety and efficacy of transplantation of human
embryonic stem cells‐derived retinal pigment epithelial (hESC‐RPE) cells in early‐stage of …