Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities
N Schneider, Y Sundaresan, P Gopalakrishnan… - Progress in retinal and …, 2022 - Elsevier
Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …
Bio-inspired flexible electronics for smart E-skin
B Nie, S Liu, Q Qu, Y Zhang, M Zhao, J Liu - Acta Biomaterialia, 2022 - Elsevier
Abstract “Learning from nature” provides endless inspiration for scientists to invent new
materials and devices. Here, we review state-of-the-art technologies in flexible electronics …
materials and devices. Here, we review state-of-the-art technologies in flexible electronics …
Retinal microglia: Functions and diseases
W Fan, W Huang, J Chen, N Li, L Mao, S Hou - Immunology, 2022 - Wiley Online Library
Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …
contributions to the maintenance of normal homeostasis and immune surveillance of these …
[HTML][HTML] Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors
Age-related macular degeneration and other macular diseases result in the loss of light-
sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor …
sensing cone photoreceptors, causing irreversible sight impairment. Photoreceptor …
Chemical reprogramming for cell fate manipulation: methods, applications, and perspectives
J Wang, S Sun, H Deng - Cell Stem Cell, 2023 - cell.com
Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …
and generate desired cell types including pluripotent stem cells for applications in …
Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies
Retinal diseases constitute a genetically and phenotypically diverse group of clinical
conditions leading to vision impairment or blindness with limited treatment options …
conditions leading to vision impairment or blindness with limited treatment options …
Nanotube‐like processes facilitate material transfer between photoreceptors
AA Kalargyrou, M Basche, A Hare, EL West… - EMBO …, 2021 - embopress.org
Neuronal communication is typically mediated via synapses and gap junctions. New forms
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs) …
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs) …
[HTML][HTML] Primary cilia biogenesis and associated retinal ciliopathies
The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …
environment and modulates diverse signaling pathways in different cell types and tissues …
Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming
Neural cell diversity is essential to endow distinct brain regions with specific functions.
During development, progenitors within these regions are characterized by specific gene …
During development, progenitors within these regions are characterized by specific gene …
A phase I clinical trial of human embryonic stem cell‐derived retinal pigment epithelial cells for early‐stage Stargardt macular degeneration: 5‐years' follow‐up
SY Li, Y Liu, L Wang, F Wang, TT Zhao, QY Li… - Cell …, 2021 - Wiley Online Library
Objectives To evaluate the long‐term biosafety and efficacy of transplantation of human
embryonic stem cells‐derived retinal pigment epithelial (hESC‐RPE) cells in early‐stage of …
embryonic stem cells‐derived retinal pigment epithelial (hESC‐RPE) cells in early‐stage of …