Sleep is highly conserved across evolution, suggesting vital biological functions that are yet
to be fully understood. Animals and humans experiencing partial sleep restriction usually …

Depending on its nature, duration, and intensity, stress can exert potent and bidirectional
modulatory effects on pain, either reducing pain (stress-induced analgesia) or exacerbating …

Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons,
which may contribute to nerve injury-induced neuropathic pain. DNA methylation represses …

Extended daytime and nighttime activities are major contributors to the growing sleep
deficiency epidemic,, as is the high prevalence of sleep disorders like insomnia. The …

Spontaneous pain, a major complaint of patients with neuropathic pain, has eluded study
because there is no reliable marker in either preclinical models or clinical studies. Here, we …

Patients in the perioperative period usually present with different types and degrees of sleep
disorders, which can severely affect their post-operative outcomes. Multiple risk factors may …

Introduction Sleep disturbances increase pain sensitivity in clinical and preclinical settings,
but the precise mechanisms are unknown. This represents a major public health issue …

Experimental studies highlight profound effects of sleep disruptions on pain, showing that
sleep deprivation (SD) leads to hyperalgesic pain changes. On the other hand, given that …

Study objective To evaluate the effects of postoperative dexmedetomidine infusion on sleep
quality in patients undergoing abdominal hysterectomy. Design Randomized, double-blind …

Objectives: The aim of our study was to compare the effect of using dexmedetomidine (DEX)
during the daytime operation or the nighttime operation under general anesthesia on …