Complex I (CI) is the largest protein complex in the mitochondrial oxidative phosphorylation
electron transport chain of the inner mitochondrial membrane and plays a key role in the …

Antiviral nucleoside and nucleotide analogs, essential for the treatment of viral infections in
the absence of efficient vaccines, are prodrug forms of the active compounds that target the …

Proteomics has revealed that the~ 20,000 human genes engender a far greater number of
proteins, or proteoforms, that are diversified in large part by post-translational modifications …

Sequences and structures of all P-loop-fold proteins were compared with the aim of
reconstructing the principal events in the evolution of P-loop-containing kinases. It is shown …

To understand the molecular mechanism underlying phosphoryl transfer of cAMP-
dependent protein kinase, the structure of the catalytic subunit in complex with ADP …

Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides
deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential …

Inorganic polyphosphate is a ubiquitous, linear biopolymer built of up to thousands of
phosphate residues that are linked by energy-rich phosphoanhydride bonds. Polyphosphate …

Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides and activate a number
of medically important nucleoside analogs. Here we report the structure of the Drosophila …

Recently, thymidine monophosphate kinase (TMPK) emerged as an attractive target for
developing inhibitors of Mycobacterium tuberculosis growth. The elucidation of the X-ray …

The chemical synthesis of new compounds designed as inhibitors of Mycobacterium
tuberculosis TMP kinase (TMPK) is reported. The synthesis concerns TMP analogues …