Detection, diagnosis and treatment of acute ischemic stroke: current and future perspectives

S Patil, R Rossi, D Jabrah, K Doyle - Frontiers in medical technology, 2022 - frontiersin.org
Stroke is one of the leading causes of disability worldwide. Early diagnosis and treatment of
stroke are important for better clinical outcome. Rapid and accurate diagnosis of stroke …

Mechanisms of fibrinolysis resistance and potential targets for thrombolysis in acute ischaemic stroke: lessons from retrieved stroke emboli

W Brinjikji, OM Mereuta, D Dai, DF Kallmes… - Stroke and Vascular …, 2021 - svn.bmj.com
There has been growing interest and insight into the histological composition of retrieved
stroke emboli. One of the main focuses of the stroke clot analysis literature has been the …

Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from …

R Rossi, S Molina, OM Mereuta, A Douglas… - Journal of …, 2022 - Springer
Background and purpose There is still much debate whether bridging-therapy [intravenous
thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to …

Composition, treatment, and outcomes by radiologically defined thrombus characteristics in acute ischemic stroke

S Das, ED Goldstein, A de Havenon, M Abbasi… - Stroke, 2023 - Am Heart Assoc
Occlusive and nonocclusive cervicocephalic thrombi can be encountered during
neurovascular imaging in patients with acute ischemic stroke. Radiographic and …

Intra-arterial tenecteplase is safe and may improve the first-pass recanalization for acute ischemic stroke with large-artery atherosclerosis: the BRETIS-TNK trial

ZA Zhao, J Qiu, L Wang, YG Zhao, XH Sun, W Li… - Frontiers in …, 2023 - frontiersin.org
Background and purpose The first-pass recanalization of endovascular treatment (EVT) is
closely correlated with clinical outcome of patients with large vessel occlusion (LVO) stroke …

Aspects of ischemic stroke biomechanics derived using ex-vivo and in-vitro methods relating to mechanical thrombectomy

R McCarthy, M Mirza, S Johnson, A Dwivedi… - Journal of …, 2022 - Elsevier
Establishing the underlying biomechanics of acute ischemic stroke (AIS) and its treatment is
fundamental to developing more effective clinical treatments for one of society's most …

[HTML][HTML] Characterization of the 'White'appearing clots that cause acute ischemic stroke

OM Mereuta, R Rossi, A Douglas, SM Gil… - Journal of Stroke and …, 2021 - Elsevier
Objectives Most clots retrieved from patients with acute ischemic stroke are 'red'in
color.'White'clots represent a less common entity and their histological composition is less …

S100b in acute ischemic stroke clots is a biomarker for post-thrombectomy intracranial hemorrhages

R Rossi, A Douglas, SM Gil, D Jabrah, A Pandit… - Frontiers in …, 2023 - frontiersin.org
Background and purpose Post-thrombectomy intracranial hemorrhages (PTIH) are
dangerous complications of acute ischemic stroke (AIS) following mechanical …

Fibrin-targeted nanoparticles for finding, visualizing and characterizing blood clots in acute ischemic stroke

ML Alonso-Alonso, M Pérez-Mato, A Sampedro-Viana… - Pharmaceutics, 2022 - mdpi.com
Recanalization of the occluded artery is the gold standard treatment for acute ischemic
stroke, which includes enzymatic fibrinolytic treatment with the use of recombinant tissue …

Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: impact of thrombus size on number of passes for clot …

R Rossi, S Fitzgerald, SM Gil… - European Stroke …, 2021 - journals.sagepub.com
Introduction We assessed the correlation between thrombus size before and after
mechanical thrombectomy, measured as length by Computed Tomography …