[HTML][HTML] NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
Modulation of oxidative stress as an anticancer strategy
The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …
responses to anticancer therapies. Many signalling pathways that are linked to …
[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance
I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …
regulating genome integrity, cell division and death. The integrity of cellular genome is …
The role of oxidative stress on breast cancer development and therapy
F Hecht, CF Pessoa, LB Gentile, D Rosenthal… - Tumor biology, 2016 - Springer
Reactive oxygen species (ROS) are produced by both enzymatic and non-enzymatic
systems within eukaryotic cells and play important roles in cellular physiology and …
systems within eukaryotic cells and play important roles in cellular physiology and …
[HTML][HTML] BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
Oxidative stress plays an important role in cancer development and treatment. Recent data
implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular …
implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular …
Redox regulation in cancer: a double‐edged sword with therapeutic potential
A Acharya, I Das, D Chandhok… - Oxidative medicine and …, 2010 - Wiley Online Library
Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the
production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS …
production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS …
[HTML][HTML] Interfering with ROS metabolism in cancer cells: the potential role of quercetin
A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …
The role of oxidative stress modulators in breast cancer
H Gurer-Orhan, E Ince, D Konyar… - Current medicinal …, 2018 - ingentaconnect.com
Background: Latest data from International Agency for Cancer Research shows that breast
cancer is the leading cancer site in women and is the leading cause of death among female …
cancer is the leading cancer site in women and is the leading cause of death among female …
PALB2/FANCN: recombining cancer and Fanconi anemia
M Tischkowitz, B Xia - Cancer research, 2010 - AACR
Partner and localizer of BRCA2 (PALB2) was originally identified as a BRCA2-interacting
protein that is crucial for key BRCA2 genome caretaker functions. It subsequently became …
protein that is crucial for key BRCA2 genome caretaker functions. It subsequently became …
Reactive oxygen species (ROS): Critical roles in breast tumor microenvironment
Increases in Reactive oxygen species (ROS) have been reported in breast tumors and their
surrounding tumor microenvironment (TME) cells. ROS are critical factors in breast TME as …
surrounding tumor microenvironment (TME) cells. ROS are critical factors in breast TME as …