The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

Reactive oxygen species (ROS) are produced by both enzymatic and non-enzymatic
systems within eukaryotic cells and play important roles in cellular physiology and …

Oxidative stress plays an important role in cancer development and treatment. Recent data
implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular …

Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the
production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS …

A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …

Background: Latest data from International Agency for Cancer Research shows that breast
cancer is the leading cancer site in women and is the leading cause of death among female …

Partner and localizer of BRCA2 (PALB2) was originally identified as a BRCA2-interacting
protein that is crucial for key BRCA2 genome caretaker functions. It subsequently became …

Increases in Reactive oxygen species (ROS) have been reported in breast tumors and their
surrounding tumor microenvironment (TME) cells. ROS are critical factors in breast TME as …