The role of adipokines in chronic inflammation

P Mancuso - ImmunoTargets and therapy, 2016 - Taylor & Francis
Adipose tissue has traditionally been defined as connective tissue that stores excess
calories in the form of triacylglycerol. However, the physiologic functions attributed to …

Integrative physiology of pneumonia

LJ Quinton, AJ Walkey, JP Mizgerd - Physiological reviews, 2018 - journals.physiology.org
Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Role of anti-inflammatory adipokines in obesity-related diseases

K Ohashi, R Shibata, T Murohara, N Ouchi - Trends in endocrinology & …, 2014 - cell.com
Obesity results in many health complications. Accumulating evidence indicates that the
obese state is characterized by chronic low-grade inflammation, thereby leading to the …

When two pandemics meet: why is obesity associated with increased COVID-19 mortality?

SM Lockhart, S O'rahilly - Med, 2020 - cell.com
A growing body of evidence indicates that obesity is strongly and independently associated
with adverse outcomes of COVID-19, including death. By combining emerging knowledge of …

COVID-19 severity in obesity: leptin and inflammatory cytokine interplay in the link between high morbidity and mortality

R Maurya, P Sebastian, M Namdeo… - Frontiers in …, 2021 - frontiersin.org
Obesity is one of the foremost risk factors in coronavirus infection resulting in severe illness
and mortality as the pandemic progresses. Obesity is a well-known predisposed chronic …

“Obesity paradox” in acute respiratory distress syndrome: asystematic review and meta-analysis

G Zhi, W Xin, W Ying, X Guohong, L Shuying - PloS one, 2016 - journals.plos.org
Background It is unclear whether an “obesity paradox” exists in the respiratory system,
especially in acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) …

[HTML][HTML] Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting MAPK and NF-κB and activating …

H Lv, Z Yu, Y Zheng, L Wang, X Qin… - International journal of …, 2016 - ncbi.nlm.nih.gov
Oxidative damage and inflammation are closely associated with the pathogenesis of acute
lung injury (ALI). Thus, we explored the protective effect of isovitexin (IV), a …

Anti-inflammatory and anti-atherogenic properties of adiponectin

K Ohashi, N Ouchi, Y Matsuzawa - Biochimie, 2012 - Elsevier
Obesity-related disorders, such as insulin resistance, hypertension and atherosclerosis, are
associated with chronic inflammation. Adiponectin is an adipocyte-derived secreted factor …

Adiponectin, leptin, and resistin are dysregulated in patients infected by SARS-CoV-2

F Perrotta, F Scialò, M Mallardo, G Signoriello… - International Journal of …, 2023 - mdpi.com
Obesity, through adipose tissue (AT) inflammation and dysregulation, represents a critical
factor for COVID-19; here, we investigated whether serum levels of adiponectin, HMW …

Adiponectin in inflammatory and immune-mediated diseases

G Fantuzzi - Cytokine, 2013 - Elsevier
Circulating levels of adiponectin (APN) are reduced in obesity and associated comorbidities,
with inflammation playing an important role in downregulating APN production. In contrast to …