Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic
chemistry due to their widespread applications in drug discovery and development. MCRs …

In the current Perspective article, we critically review and discuss the importance of solvent
effects on multicomponent reactions, likely the most neglected aspect in this research field …

The development of novel therapeutics promoting selective tumor elimination is the
mainstay of clinical oncology. Emerging insights into tumor targeting reveal caspases …

Environmental issues are becoming more and more prominent, and bio‐based polymers are
essential to alleviate environmental degradation by replacing traditional polymers. With this …

With their three points of diversity, α-acyloxy carboxamides, which are accessible with the
Passerini reaction, provide heterogeneity for the preparation of libraries of putative active …

A metal-free three-component protocol that combines a hydroxylamine-Passerini reaction
and hetero-Cope rearrangement was realized, which enables the modular assembly of a …

The Passerini coupling of cinnamaldehyde derivatives affords allylic esters that may behave
as both electrophiles and nucleophiles in Tsuji–Trost reactions. We present herein the …

Multicomponent reactions were performed to develop novel α, β-unsaturated carbonyl
depsipeptides and peptoids incorporating various chromophores such as cinnamic …

Protein‐templated fragment ligation was established as a method for the rapid identification
of high affinity ligands, and multicomponent reactions (MCR) such as the Ugi four …

A facile one-pot synthesis of dihydroisobenzofuran derivatives by Passerini-azide/Ag (I)-
catalyzed cyclization sequence has been developed. The Passerini-azide reactions of 2 …