Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons
and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory …

The mesolimbic dopamine system—which originates in the ventral tegmental area and
projects to the striatum—has been shown to be involved in the expression of sex-specific …

The rotarod test is widely used to evaluate the motor coordination of rodents, and is
especially sensitive in detecting cerebellar dysfunction. However, mice with striatal …

The fundamental principle that unites addictive drugs appears to be that each enhances
synaptic dopamine by means that dissociate it from normal behavioral control, so that they …

Summary mTOR is a regulator of cell growth and survival, protein synthesis-dependent
synaptic plasticity, and autophagic degradation of cellular components. When triggered by …

Dopamine (DA) D2 receptors expressed in DA neurons (D2 autoreceptors) exert a negative
feedback regulation that reduces DA neuron firing, DA synthesis and DA release. As D2 …

Dopamine (DA) is a key transmitter in the basal ganglia, yet DA transmission does not
conform to several aspects of the classic synaptic doctrine. Axonal DA release occurs …

The manifestations of Parkinson's disease are caused by reduced dopaminergic innervation
of the striatum. Loss-of-function mutations in the DJ-1 gene cause early-onset familial …

Midbrain dopaminergic neurons are essential for appropriate voluntary movement, as
epitomized by the cardinal motor impairments arising in Parkinson's disease. Understanding …