Silicone is a synthetic polymer widely used in the biomedical industry as implantable
devices since 1940, owing to its excellent mechanical properties and biocompatibility …

Guided tissue regeneration (GTR) has been widely used in the periodontal treatment of
intrabony and furcation defects for nearly four decades. The treatment outcomes have …

Mesenchymal stem/stromal cells (MSCs) are adult multipotent stem cells. Here, we induced
MSCs from human induced pluripotent stem cells (iPSCs) via a neural crest cell (NCC) …

Nerve guidance conduits (NGCs) are sub-optimal for long-distance injuries with
inflammation and poor vascularization related to poor axonal repair. This study used a multi …

The pursuit of effective therapeutic strategies for tissue damage has prompted extensive
scholarly investigations worldwide. Tissue engineering has emerged as a prominent …

Despite the advances in tissue engineering approaches, reconstruction of long segmental
peripheral nerve defects remains unsatisfactory. Although autologous grafts with proper …

Injury to the peripheral nerve causes potential loss of sensory and motor functions, and
peripheral nerve repair (PNR) remains a challenging endeavor. The current clinical methods …

The laryngotracheal cartilage is a cardinal framework for the maintenance of the airway for
breathing, which occasionally requires reconstruction. Because hyaline cartilage has a poor …

Stem cell therapy is a current world-wide topic in medical science. Various therapies have
been approved based on their effectiveness and put into practical use. In Japan, research …

Objective. Engineered nerve conduits must simultaneously enhance axon regeneration and
orient axon extension to effectively restore function of severely injured peripheral nerves …