Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Eukaryotic cells sterilize the cytosol by using autophagy to route invading bacterial
pathogens to the lysosome. During macrophage infection with Mycobacterium tuberculosis …

Professional phagocytes have a vast and sophisticated arsenal of microbicidal features.
They are capable of ingesting and destroying invading organisms, and can present …

Cytosolic bacterial pathogens activate the cytosolic surveillance pathway (CSP) and induce
innate immune responses, but how the host detects vacuolar pathogens like Mycobacterium …

Listeria monocytogenes has, in 25 y, become a model in infection biology. Through the
analysis of both its saprophytic life and infectious process, new concepts in microbiology …

Listeriolysin O (LLO) is a toxin produced by Listeria monocytogenes, an opportunistic
bacterial pathogen responsible for the disease listeriosis. This disease starts with the …

Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can
invade non-phagocytic cells and survive within a membrane-bound compartment. However …

Abstract Background The Amoebozoa constitute one of the primary divisions of eukaryotes,
encompassing taxa of both biomedical and evolutionary importance, yet its genomic …

Phagocytes are crucial for host defense against bacterial pathogens. As first demonstrated
by Metchnikoff, neutrophils and mononuclear phagocytes share the capacity to engulf, kill …